Qhov ncauj yaug ntawm lub neej yav tom ntej

Puas yog ib qho tshuaj tua kab mob uas tau muab rho tawm los ntawm cov txiv kab ntxwv qaub tuaj yeem yog qhov sib npaug ntawm Chlorhexidine rau qhov ncauj yaug? Danny Chan tau txais cov ntsiab lus los ntawm cov kws tshaj lij tshuaj plaque tswj, Dr Tihana Divnic-Resnik.

Citrox® yog ib qho tshuaj tua kab mob zoo heev uas tuaj yeem siv rau hauv lub cim tshiab ntawm cov tshuaj ntxuav qhov ncauj.

Thaum nws cov khoom muaj zog tiv thaiv kab mob thiab cov tshuaj tiv thaiv kab mob tau zoo li cov Chlorhexidine (CHX) - tam sim no yog ib qho ntawm cov tshuaj tua kab mob ntau tshaj plaws rau kev tswj cov quav hniav - Citrox® tau pom qee cov txiaj ntsig uas tuaj yeem ua rau nws muaj riam phom loj hauv kev sib ntaus sib tua ntawm qhov ncauj. cov quav hniav.

Txawm hais tias tseem muaj hnub nyoog ntxov, qhov kev sim thawj zaug tau los txog tam sim no tau zoo.

"Peb ntseeg tias Citrox® tau ua pov thawj nws tus kheej yog ib qho tseem ceeb hauv cov tshuaj ntxuav qhov ncauj kom zoo thiab ua ke nrog cyclodextrins, yuav ua lub luag haujlwm tseem ceeb hauv kev kho qhov ncauj yav tom ntej," hais txog Dr Tihana Divnic-Resnik.

Dr Divnic-Resnik yog ib tus kws tshawb fawb hauv tsev kawm qib siab uas kawm txog qhov muaj peev xwm siv Citrox® ua ib feem ntawm kev tshawb fawb dav dav rau ntau txoj hauv kev ntawm kev tswj cov tshuaj plaque. Nws kuj tseem koom nrog hauv kev tshawb fawb ntawm Curaden's CURAPROX Perio Plus +, ib qho tshuaj tua kab mob hauv qhov ncauj uas ua ke Chlorhexidine nrog Citrox®.

Dr Tihana Divnic-Resnik yog Senior Lecturer ntawm University of Sydney. Tau 10 xyoo, nws tau ua tus kws qhia ntawv hauv Periodontics thiab Oral Medicine hauv University of Belgrade, Serbia, qhov chaw nws kuj tau xyaum ua tus kws tshaj lij ntawm Periodontology thiab Oral Medicine.

Tam sim no nws tab tom ua haujlwm ntawm Department for Periodontics ntawm Sydney Dental Hospital. Dr Divnic-Resnik kawm tiav qib Master thiab PhD hauv Periodontology.

Ib feem ntawm koj qhov kev tshawb fawb suav nrog debunking myths nyob ib puag ncig kev siv tshuaj plaque tswj hauv kev kho hniav kho hniav. Vim li cas koj xav tias cov kev xav tsis zoo no muaj nyob hauv thawj qhov chaw thiab koj yuav ua li cas los daws lawv?

Dr Tihana Divnic-Resnik: Muaj ntau cov lus dab neeg hais txog kev tswj cov quav hniav, vim nws siv txuas mus rau cov kev vam meej thaum ub uas siv lub qhov ncauj ntxuav hauv kev tiv thaiv thiab kho ntau yam kab mob ntawm qhov ncauj, suav nrog gingivitis thiab periodontitis.

Kev ua lag luam thoob ntiaj teb yog loaded nrog cov khoom tshiab. Nyob rau hauv lub siab mus muag, manufacturers yog tej zaum nthuav lawv cov khoom nyob rau hauv qhov zoo tshaj plaws lub teeb uas tsim misconceptions tias cov khoom yuav ua tau zoo dua li qhov nws yog tiag tiag, tsis quav ntsej tej yam kev mob tshwm sim.

Txawm li cas los xij, los ntawm kev tiv thaiv, nws yog ib qho tseem ceeb uas yuav tsum tau hais tias kev tswj cov tshuaj plaque yuav tsum tsis txhob siv niaj hnub siv thiab cov tshuaj tua kab mob hauv qhov ncauj yuav tsum tau siv los ua ke rau kev tswj cov quav hniav.

Kev tswj cov quav hniav nrog txhuam hniav thiab txhuam hniav / txhuam hniav yog qhov tseem ceeb tshaj plaws thiab kev xaiv thawj zaug hauv kev tu cev tsis tu ncua. Kev siv cov tshuaj tua kab mob hauv qhov ncauj tuaj yeem txo cov kab mob colonization thiab txo cov gingival o.

Raws li cov kws kho hniav, peb yuav tsum paub txog cov ntaub ntawv pov thawj tsis ntev los no thiab xaiv cov khoom uas tau sim thiab ua pov thawj tias muaj txiaj ntsig zoo thiab nyab xeeb rau peb cov neeg mob.

Chlorhexidine yog ib qho ntawm cov tshuaj tua kab mob uas siv ntau tshaj plaws rau kev tswj cov quav hniav, tab sis koj kuj tseem qhia txog nws qhov kev cuam tshuam tsis zoo ntawm kev hloov xim. Cov kws kho hniav puas tseem xav kom yaug cov tshuaj Chlorhexidine?

TDR: Chlorhexidine (CHX) yog cov ntaub ntawv zoo thiab muaj txiaj ntsig zoo tshuaj tua kab mob siv rau kev tiv thaiv thawj thiab theem nrab ntawm gingivitis thiab periodontitis raws li ib qho ntxiv rau kev tswj cov quav hniav. Feem ntau, nws yog siv los ua tshuaj tua kab mob qhov ncauj yaug ntawm ntau qhov ntau ob zaug hauv ib hnub rau txog plaub lub lis piam.

Txawm hais tias CHX nthuav tawm dav cov tshuaj tiv thaiv kab mob thiab muaj cov txiaj ntsig zoo, nws qhov tsis zoo yog nws lub peev xwm los stain cov hniav thiab cov khoom siv kho kom zoo nkauj.  

Hauv ob peb xyoos tsis ntev los no, vim kev siv dav dav ntawm CHX tsis yog hauv kev kho hniav nkaus xwb tab sis kuj yog tshuaj kho mob, kev txhawj xeeb tau tshwm sim los ntawm kev nce tus naj npawb ntawm kev tsis haum rau CHX nrog rau kev txhim kho microbial kam rau ua. Cov kev xav tsis zoo li no tau ua rau muaj kev hu xov tooj rau kev hloov kho kho mob thiab tshawb nrhiav lwm yam tshuaj rau kev kho qhov ncauj.

Txog thaum cov txheej txheem tshiab tau tsim, CHX tseem yog ib qho kev xaiv zoo hauv kev xyaum - muab cov kws kho hniav thiab cov neeg mob paub txog nws qhov kev cuam tshuam tsis zoo.

Dab tsi koj tuaj yeem qhia peb txog Citrox® thiab nws lub peev xwm siv los ua cov khoom xyaw hauv kev tsim cov tshuaj tua kab mob qhov ncauj, gel thiab tshuaj txhuam hniav?

TDR: Hauv ob peb xyoos dhau los, phytopharmaceuticals tau lees paub tias muaj lub luag haujlwm tseem ceeb hauv kev xa tshuaj tshiab. Bioflavonoids yog polyphenolic compounds, pom nyob rau hauv cov nroj tsuag, nrog pov thawj cov txiaj ntsig kev noj qab haus huv. Citrox® yog ib qho kuab tshuaj uas muaj cov tshuaj bioflavonoid complex, muab tau los ntawm cov Citrus aurantius (txiv kab ntxwv qaub), thiab organic acids.

Cov kev tshawb fawb tau pom tias nws muaj zog tiv thaiv kab mob, tiv thaiv kab mob, thiab tiv thaiv oxidative muaj peev xwm. Citrox® muaj cov tshuaj tua kab mob dav dav thiab muaj txiaj ntsig zoo tiv thaiv kab mob, kab mob, thiab fungi. Nws cov txheej txheem ntawm kev ua ntawm qib cellular zoo ib yam li CHX.

Tsis tas li ntawd, Citrox® tuaj yeem txo qis cov kab mob microbial los ntawm kev tsom mus rau lawv cov enzymes thiab kev ua phem, yog li txo lawv cov peev xwm ua rau muaj kab mob. Cov cuab yeej no yog qhov tseem ceeb hauv kev sib ntaus sib tua CHX cov kab mob uas tau tsim kev zam rau qee yam tshuaj tua kab mob.

Siv ua ke nrog CHX hauv PerioPlus +, Citrox® tau qhia txog kev ua haujlwm sib koom ua ke, uas tuaj yeem ua rau siv qis dua ntawm CHX hauv cov khoom noj qab haus huv ntawm qhov ncauj thiab tom qab ntawd txo qis nws cov teebmeem.

Peb ntseeg tias Citrox® tau ua pov thawj nws tus kheej yog ib qho tseem ceeb hauv cov tshuaj ntxuav qhov ncauj kom zoo thiab ua ke nrog cyclodextrins, yuav ua lub luag haujlwm tseem ceeb hauv kev kho qhov ncauj yav tom ntej.

Raws li koj txoj kev tshawb fawb ntawm cov hniav staining los ntawm kev lag luam qhov ncauj, koj puas xav tias Citrox® tuaj yeem pab daws qhov teeb meem? Yog muaj, ua li cas?

TDR: Txo cov concentration ntawm CHX thiab ntxiv rau nws nrog lwm cov tshuaj tua kab mob xws li Citrox®, yuav ua rau txo cov kev mob tshwm sim, thaum tswj cov tshuaj tua kab mob. Peb nyob rau hauv vitro txoj kev tshawb no sim discoloration muaj peev xwm ntawm PerioPlus + qhov ncauj qhov ncauj ntawm ncaj qha aesthetic restorative cov ntaub ntawv xws li composite resins thiab iav ionomer cements.

Hauv peb qhov kev ntsuam xyuas, PerioPlus + cov tshuaj ntxuav qhov ncauj ua rau muaj qhov tsis zoo hauv cov qauv ntawm cov khoom siv zoo nkauj, piv rau cov ntsiab lus zoo sib xws ntawm CHX. Thaum cov txiaj ntsig thawj zaug tau pom zoo, cov no tseem yog hnub ntxov, thiab cov kev tshawb fawb ntxiv yog tsim nyog los piav qhia lub luag haujlwm ntawm Citrox® hauv kev txo lossis tiv thaiv staining.

Puas yog koj qhov kev tshawb fawb ntawm Perio Plus qhia tias nws yog ib kauj ruam hauv kev coj ncaj ncees thaum nws los tsim "ntxuav" yav tom ntej?

TDR: Cov txiaj ntsig zoo ntawm nyob rau hauv vitro Cov kev tshawb fawb pom tau tias muaj peev xwm ntawm PerioPlus + kom kov yeej qee qhov tsis zoo ntawm CHX.

Txawm li cas los xij, kev tshawb fawb soj ntsuam yuav tsum tau ua kom paub meej nyob rau hauv vitro cov txiaj ntsig thiab txhawm rau tshawb nrhiav ntau yam kev qhia rau nws qhov kev siv tshuaj kho mob.  

Tam sim no, peb tab tom tsim cov kev tshawb fawb soj ntsuam nrog peb cov npoj yaig los ntawm Tebchaws Europe, thiab University of Sydney yuav yog ib qho ntawm thawj lub chaw kuaj mob PerioPlus + qhov ncauj ntxuav hauv chaw kho mob.

Peb kuj tseem tsom mus txuas ntxiv tshawb nrhiav ntau yam khoom xyaw ntuj uas yuav tsim cov qauv rau cov khoom kho qhov ncauj yav tom ntej.

References

Hooper SJ, Lewis MA, Wilson MJ, Williams DW. Antimicrobial kev ua ntawm Citrox bioflavonoid npaj tawm tsam cov kab mob hauv qhov ncauj. Br Dent J. 2011 Jan 8;210(1):E22. doi: 10.1038/sj.bdj.2010.1224. PIB: 21217705

Jeyakumar J, Sculean A, Eick S. Anti-biofilm Kev Ua Haujlwm ntawm Cov Khoom Siv Kho Hniav Qhov ncauj uas muaj Chlorhexidine Digluconate thiab Citrox. Oral Health Prev Dent. 2020 Lub Kaum Ob Hlis 27; 18(1): 981-990. doi: 10.3290/j.ohpd.a45437. PIB: 33215489

Malic S et al. Antimicrobial kev ua ntawm cov qhov ncauj tshiab tawm tsam cov hlwb planktonic thiab biofilms ntawm pathogenic microorganisms. Microbiology Discovery 2013 Microbiology Discovery. Doi: 10.7243/2052-6180-1-11.