Oral Microbiome Transplants Show Promise in Preventing Dental Decay, Study Reveals

AUSTRALIA: Researchers from the University of Adelaide have embarked on a trial exploring the potential of oral microbiome transplants in preventing dental caries, with early findings indicating promising results.

The procedure involves transferring beneficial bacteria from a healthy oral microbiome to individuals lacking a diverse range of good bacteria in their mouths. The researchers propose delivering these transplants through plaque samples incorporated into toothpaste or gel.

Positive Pre-Clinical Trial Results

Preliminary results from a pre-clinical trial have shown that oral microbiome transplants effectively suppressed dental caries without adverse effects on other aspects of health, including the gut microbiome. The study identified over 700 types of bacteria constituting the oral microbiome.

Exploring the Oral Microbiome: Unraveling Links to Systemic Diseases

Associate Professor Peter Zilm, a researcher at the Adelaide Dental School, expressed intrigue at the mystery surrounding why some individuals naturally possess a healthy oral microbiome, regardless of regular dental visits.

The study revealed that essential bacteria for preventing tooth decay could be preserved for up to three months after collection, offering a potential solution to chronic dental issues. Professor Zilm highlighted the importance of developing a paste containing beneficial bacteria, particularly beneficial for vulnerable populations like the elderly and young children.

Identifying “super donors” with ideal bacterial profiles through a screening process developed in collaboration with Penn State University is a crucial aspect of the research. The team aims to secure funding to advance to human trials within the next two years.

Minimising Peri-implant Complications through Optimal Management of the Oral Microbiome

Addressing Oral Health as a Gateway to Overall Well-being

Professor Zilm emphasized the broader implications of oral health beyond eating and drinking, noting its correlation with overall health. Poor oral health has been linked to various medical problems such as cardiovascular disease, cancer, and birth complications. 

If proven safe for humans, oral microbiome transplants could offer a cost-effective solution to combat one of the most common chronic illnesses globally.