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ZuluTEB CHAWS USA: Cov kws tshawb fawb tau nthuav tawm txoj kev tshawb fawb tshiab los tsim lub Lipid nanoparticles (LNP) platform rau kev kho qhov ncauj squamous cell carcinoma (OSCC) siv p53 mRNA.
Qhov kev nce qib tseem ceeb no tau nthuav tawm ntawm 102nd General Session ntawm International Association for Dental, Oral, thiab Craniofacial Research (IADR), ua ke nrog 53rd Lub Rooj Sib Tham Txhua Xyoo ntawm American Association for Dental, Oral, thiab Craniofacial Research (AADOCR) thiab 48th Lub Rooj Sib Tham Txhua Xyoo ntawm Canadian Association for Dental Research.
Kev Tshawb Fawb Txheej Txheem thiab Txheej Txheem
Txoj kev tshawb no, coj los ntawm Marshall Scott Padilla ntawm University of Pennsylvania, Philadelphia, Tebchaws USA, tau tsom mus rau kev tsim lub tsev qiv ntawv ntawm LNPs nrog luciferase mRNA, uas tom qab ntawd tau sim hauv CAL-27 hlwb, tus qauv OSCC kab. Cov LNPs no tau raug soj ntsuam ntxiv los ntawm kev txhaj tshuaj rau hauv cov nas C57BL / 6 los ntsuas lawv qhov kev xav tau rau kev hloov pauv lub siab. LNPs qhia tau hais tias muaj luminescence siab nyob rau hauv CAL-27 hlwb thiab lub siab tsis tshua muaj transfection mus rau qhov kev tshuaj ntsuam tom ntej.
Nyem mus ntsib Lub vev xaib ntawm Is Nrias teb Tus Thawj Coj Chaw Tsim Khoom ntawm Cov Khoom Siv Kho Hniav Ntiaj Teb, Exported rau 90+ Lub Tebchaws.
Tom qab ob qhov kev tshuaj ntsuam xyuas, LNP E10i-494 tau nthuav tawm zoo kawg li mRNA hloov pauv hauv vitro thiab hauv ob tus qauv qog murine, thaum tswj hwm qhov kev nyab xeeb zoo nrog rau qib qis ntawm daim siab transfection.
Qhov tseem ceeb, hauv cov qauv orthotopic, E10i-494 tau nkag mus rau hauv cov qog nqaij hlav thiab cov qog nqaij hlav, tseem ceeb heev rau kev tiv thaiv qog nqaij hlav metastasis. Ntxiv mus, thaum kho dua tshiab nrog p53 mRNA, E10i-494 tau pom tias muaj zog ntawm tes tua, qhia tias nws muaj peev xwm ua tau zoo hauv OSCC txoj kev kho.
Txoj kev tshawb no yog qhov tseem ceeb hauv kev kho mob qog noj ntshav hauv qhov ncauj, raws li nws nthuav tawm qhov kev ua kom zoo tshaj plaws ntawm thawj LNP rau lub qhov ncauj kab noj hniav thiab qhia nws lub peev xwm rau p53-raws li OSCC txoj kev kho. Cov kev tshawb pom no tau cog lus rau kev txhim kho cov kev kho mob tshiab tom ntej rau kev mob qog noj ntshav hauv qhov ncauj, daws cov teeb meem tseem ceeb hauv kev kho tam sim no.
Hais txog IADR thiab AADOCR
Lub Koom Haum Thoob Ntiaj Teb rau Kev Kho Hniav, Qhov Ncauj, thiab Craniofacial Research (IADR) thiab American Association for Dental, Oral, thiab Craniofacial Research (AADOCR) yog cov koom haum tsis muaj txiaj ntsig tau mob siab rau kev tshawb fawb kho hniav, qhov ncauj, thiab craniofacial rau ntiaj teb kev noj qab haus huv thiab kev noj qab haus huv. Sawv cev rau cov kws tshawb fawb, kws kho hniav, thiab cov tub ntxhais kawm los ntawm ntau lub tsev kawm ntawv, cov koom haum no ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev sib koom tes thiab kev tsav tsheb tshiab hauv kev kho qhov ncauj.
Cov ntaub ntawv thiab cov kev xav tau nthuav tawm nyob rau hauv cov xov xwm saum toj no lossis tsab xov xwm tsis tas yuav cuam tshuam txog txoj cai los yog txoj cai ntawm Dental Resource Asia lossis DRA Journal. Thaum peb siv zog los xyuas kom meej qhov tseeb ntawm peb cov ntsiab lus, Dental Resource Asia (DRA) lossis DRA Journal tsis tuaj yeem lav qhov tseeb tas li, kev nkag siab, lossis sijhawm sijhawm ntawm tag nrho cov ntaub ntawv muaj nyob hauv lub vev xaib lossis phau ntawv xov xwm no.
Thov nco ntsoov tias tag nrho cov ntsiab lus ntawm cov khoom, cov khoom specifications, thiab cov ntaub ntawv nyob rau hauv lub website los yog phau ntawv journal tej zaum yuav raug hloov yam tsis tau txais kev ceeb toom ua ntej thiaj li yuav txhim khu kev ntseeg, functionality, tsim, los yog rau lwm yam laj thawj.
Cov ntsiab lus pab los ntawm peb cov bloggers lossis cov kws sau ntawv sawv cev rau lawv cov kev xav ntawm tus kheej thiab tsis yog tsim los rau kev thuam lossis tsis lees paub txog kev ntseeg, haiv neeg, club, koom haum, tuam txhab, tus kheej, lossis ib lub koomhaum lossis ib tus neeg twg.